BIOM-63. IDENTIFICATION OF MIRNA IN CEREBROSPINAL FLUID AND PLASMA AS A BIOMARKER TO SUPPORT MRI EVALUATION AND MONITORING OF PEDIATRIC BRAIN TUMORS

Abstract MRI is the current gold standard imaging technique for diagnostic evaluation and monitoring of pediatric CNS tumors, however measures are unable to fully relate tumor biology molecular stratification. Circulating in blood cerebrospinal fluid (CSF), miRNAs an abundant stable nucleic acid which can be utilized as a biomarker. Relating miRNA biomarkers radiological measurements may provide improved tools brain tumors. Using cohort 54 tumors including low grade glioma, ependymoma, germ cell tumor, medulloblastoma, atypical teratoid rhabdoid high-grade glioma we attempted combine findings circulating data. The expression was profiled 33 CSF 52 plasma samples using HTG EdgeSeq platform. Clinically acquired, multi-parametric scans at time-points close proximity liquid biopsy collection were collected retrospectively used generate volumetric segmentations. We identified unique targets significantly correlated with features, clinical findings, patient outcomes. In both plasma, correlate diagnosis features survival status (p < 0.05). CSF, cystic core volume, non-enhancing leptomeningeal disease, size location Combination radiomic predictions between low- location, disease These results demonstrate utility biomarker combined improve minimally non-invasive diagnostics management